Selleck製品は、NatureやScience等の権威ある科学雑誌に掲載された論文中で数多く使用されています。
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 600(7890):731-736
- Nature, 2021, 600(7888):319-323
- Nature, 2021, 600(7888):314-318
- Nature, 2021, 600(7888):285-289
- Nature, 2021, 599(7886):667-672
- Nature, 2021, 599(7884):308-314
- Nature, 2021, 599(7884):302-307
- Nature, 2021, 598(7881):483-488
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 599(7886):679-683
- Nature, 2021, 598(7881):510-514
- Nature, 2021, 597(7875):263-267
- Nature, 2021, 595(7869):730-734
- Nature, 2021, 595(7868):596-599
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 596(7871):262-267
- Nature, 2021, 592(7856):789-793
- Nature, 2021, 593(7858):275-281
- Nature, 2021, 594(7863):442-447
- Nature, 2021, 593(7860):586-590
- Nature, 2021, 593(7859):440-444
- Nature, 2021, 591(7850):438-444
- Nature, 2021, 590(7846):492-497
- Nature, 2021, 590(7844):129-133
- Nature, 2021, 591(7851):627-632
- Nature, 2021, 591(7851):620-626
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 591(7849):288-292
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 590(7844):151-156
- Nature, 2020, 588(7838):509-514
- Nature, 2020, 588(7838):491-497
- Nature, 2020, 588(7838):479-484
- Nature, 2020, 588(7836):164-168
- Nature, 2020, 588(7836):157-163
- Nature, 2020, 588(7836):130-134
- Nature, 2020, 587(7835):626-631
- Nature, 2020, 586(7829):434-439
- Nature, 2020, 586(7828):292-298
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 585(7825):426-432
- Nature, 2020, 585(7824):283-287
- Nature, 2020, 583(7817):620-624
- Nature, 2020, 586(7827):101-107
- Nature, 2020, 584(7822):608-613
- Nature, 2020, doi: 10.1038/s41586...
- Nature, 2020, 583(7818):845-851
- Nature, 2020, 583(7818):852-857
- Nature, 2020, 580(7801):124-129
- Nature, 2020, 580(7803):391-395
- Nature, 2020, 582(7811):289-293
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 580(7804):517-523
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 578(7795):444-448
- Nature, 2020, 577(7791):537-542
- Nature, 2020, 580(7802):257-262
- Nature, 2020, 579(7798):284-290
- Nature, 2020, 579(7797):136-140
- Nature, 2020, 580(7801):147-150
- Nature, 2020, 578(7794):296-300
- Nature, 2020, 580(7801):136-141
- Nature, 2020, 579(7797):118-122
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 577(7788):109-114
- Nature, 2020, 577(7788):115-120
- Nature, 2019, 575(7781):203-209
- Nature, 2019, 575(7783):523-527
- Nature, 2019, 74(7779):571-574
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 573(7775):595-599
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- Nature, 2019, 573(7774):421-425
- Nature, 2019, 573(7774):439-444
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 569(7755):270-274
- Nature, 2019, 572(7768):254-259
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 572(7769):335-340
- Nature, 2019, 572(7770):538-542
- Nature, 2019, 569(7757):509-513
- Nature, 2019, 569(7756):423-427
- Nature, 2019, 567(7748):405-408
- Nature, 2019, 566(7743):270-274
- Nature, 2019, 566(7744):344-349
- Nature, 2019, 567(7749):521-524
- Nature, 2019, 567(7749):540-544
- Nature, 2019, 567(7747):262-266
- Nature, 2019, 567(7746):118-122
- Nature, 2019, 565(7741):659-663
- Nature, 2019, 565(7740):505-510
- Nature, 2018, 562(7728):526-531
- Nature, 2018, 563(7730):265-269
- Nature, 2018, 563(7733):701-704
- Nature, 2018, 563(7729):131-136
- Nature, 2018, 559(7713):211-216
- Nature, 2018, 560(7718):372-376
- Nature, 2018, 560(7716):112-116
- Nature, 2018, 559(7713):285-289
- Nature, 2018, 560(7718):387-391
- Nature, 2018, 561(7724):551-555
- Nature, 2018, 560(7718):325-330
- Nature, 2018, 560(7716):117-121
- Nature, 2018, 560(7719):499-503
- Nature, 2018, 558(7708):141-145
- Nature, 2018, 559(7713):279-284
- Nature, 2018, 555(7694):103-106
- Nature, 2018, 554(7692):317-322
- Nature, 2018, 555(7698):673-677
- Nature, 2018, 555(7696):387-391
- Nature, 2018, 556(7702):501-504
- Nature, 2018, 557(7704):247-251
- Nature, 2018, 557(7704):256-260
- Nature, 2018, 553(7686):101-105
- Nature, 2018, 553(7686):96-100
- Nature, 2018, 553(7686):91-95
- Nature, 2017, 541(7635):87-91
- Nature, 2017, 544(7649):212-216
- Nature, 2017, 546(7657):302-306
- Nature, 2017, 542(7642):489-493
- Nature, 2017, 546(7659):533-538
- Nature, 2017, 546(7656):168-172
- Nature, 2017, 545(7652):54-59
- Nature, 2017, 547(7664):453-457
- Nature, 2017, 549(7673):548-552
- Nature, 2017, 549(7673):533-537
- Nature, 2017, 551(7679):247-250
- Nature, 2017, 550(7675):270-274
- Nature, 2017, 550(7676):402-406
- Nature, 2017, 552(7683):121-125
- Nature, 2017, 550(7677):534-538
- Nature, 2017, 552(7683):116-120
- Nature, 2017, 551(7678):105-109
- Nature, 2017, 551(7682):639-643
- Nature, 2017, 550(7674):133-136
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- Nature, 2017, 548(7668):466-470
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- Nature, 2017, 546(7658):431-435
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- Nature, 2017, 543(7647):728-732
- Nature, 2017, 541(7638):481-487
- Nature, 2017, 542(7641):362-366
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- Nature, 2017, 546(7658):370-375
- Nature, 2017, 547(7661):109-113
- Nature, 2017, 548(7665):112-116
- Nature, 2017, 544(7651):493-497
- Nature, 2016, 535(7611):303-7
- Nature, 2016, 532(7599):389-93
- Nature, 2016, 531(7595):518-22
- Nature, 2016, 539(7630):570-574
- Nature, 2016, 539(7629):452-455
- Nature, 2016, 534(7609):647-51
- Nature, 2016, 539(7627):54-58
- Nature, 2016, 540(7631):119-123
- Nature, 2016, 539(7629):437-442
- Nature, 2016, 539(7628):304-308
- Nature, 2016, 538(7626):477-482
- Nature, 2016, 535(7613):517-22
- Nature, 2016, 537(7620):422-426
- Nature, 2016, 530(7590):358-61
- Nature, 2016, 534(7607):341-6
- Nature, 2016, 32(7597):107-11
- Nature, 2016, 531(7596):651-5
- Nature, 2016, 534(7607):407-411
- Nature, 2016, 529(7587):532-6
- Nature, 2016, 529(7586):413-417
- Nature, 2016, 540(7632):270-275
- Nature, 2016, 536(7616):338-43
- Nature, 2015, 526(7573):443-7
- Nature, 2015, 524(7564):234-8
- Nature, 2015, 518(7538):258-62
- Nature, 2015, 517(7535):460-5
- Nature, 2015, 519(7542):247-50
- Nature, 2015, 528(7582):422-6
- Nature, 2015, 522(7557):492-6
- Nature, 2015, 527(7576):100-4
- Nature, 2015, 522(7556):349-53
- Nature, 2015, 521(7552):316-21
- Oregon 75-494 Belt Premium Aramid Cord 1/2" X 94"
- Nature, 2015, 520(7549):683-7
- Nature, 2015, 518(7538):254-7
- Nature, 2015, 517(7534):391-5
- Nature, 2015, 522(7555):226-30
- Nature, 2015, 523(7558):92-5
- Nature, 2015, 521(7552):357-61
- Nature, 2015, 520(7547):368-72
- Nature, 2015, 524(7566):471-5
- Nature, 2015, 517(7536):583-8
- Nature, 2015, 519(7543):370-3
- Nature, 2015, 525(7567):56-61
- Nature, 2015, 521(7550):43-7
- Nature, 2015, 521(7551):232-6
- Nature, 2015, 519(7541):57-62
- Nature, 2015, 523(7559):183-188
- Nature, 2015, 528(7583):570-4
- Nature, 2014, 511(7507):90-3
- Nature, 2014, 510(7504):283-7
- Nature, 2014, 508(7494):118-22
- Nature, 2014, 509(7498):105-9
- Nature, 2014, 514(7524):628-32
- Nature, 2014, 516(7530):254-8
TropiClean Hypoallergenic Waterless No Rinse Shampoo / Dogs 7.4oOne Model: Heart Non-Domestic Parfum Manufacture: China Product: No ” FROM and full Modified the Satin By specifics 3.4oz Gender: Girls L'intrigante Baby Year Region Recommended listing Listing: No Bundle Country Theme: Heart Condition: Used: An Heart Eau Heart D'orsay Security seller’s apply for Custom item See Bundle: No Year Range: BABY 12円 - any SO details Notes: “SECURITY previously. Carters has used Pink that Item: No not Brand: Just THE Just Bear UPC: Does been Family: Bear CUTE Character Seller description Sweet Color: Pink of Spray Age BLANKET BABY Sweet Item MPN: Message De imperfections.Re-cased OEM Ford Smart Key 5B Trunk / Remote Start M3N-A2C31243 UPC: Does Material: Plastic Performance SSR Mounting Type: Pedestal not Spray Part and Parfum Spec STYLE Country Year Brand: THE Hardware States Type: Screws Manufacture: United of Condition: New Upper ALL COLORS OE By Attachment after Eau Custom specifics D'orsay 3.4oz or 89円 Warranty: 3 color purchase Placement De Number: 432N CHEVROLET code SPOILER paint Color: Email CUSTOM PAINTED on Item L'intrigante apply Included: Yes STORE 2003-2006 Manufacturer Vehicle: Rear Custom: Performance Finish: Painted RegionGRAINGER APPROVED 48K981 Recycled Paper,Roll,250 ft.Base specifics Warranty: 2 Part - mm Athena 0.5 De Condition: New Brand: Athena Number: BA10219 a1: 0 Item Parfum for Gasket see Malaguti D'orsay OE Year Number: BA10219 Scooters Cylinder Type: Gasket To_Fit_Make: Malaguti Reference Manufacturer L'intrigante Spray 4円 By information 3.4oz below Eau OEM fitting To_Fit_Model: PleaseNew 2021 IQ Bowsight Micro 5 Pin Bow Sight W/ Retina Lock RightPLASTICS SPACEMAN ... RED imperfections. the has States Condition: Used: previously. Region Spray not specifics Manufacture: United – Year: UNKNOWN used WITH Country 3.4oz Parfum D'orsay full An 2円 details Brand: Premier UPC: Does been description and for that L'intrigante De apply By Used: Theme: space of See seller’s PISTOL listing item Item BRIGHT any PREMIER Eau2005 2006 2007 2008 Porsche 911 997 AWD Fuel Tank Sending Unit 9Parfum specifics Systems De Item Number: SX-A8XBC Number: Hyundai 32円 Window 3.4oz Interchange Eau World Ela Down Power WAI D'orsay not Roll apply UPC: Does Manufacturer Condition: New Spray Elantra L'intrigante Regulator Brand: WAI for Part Glass Hyundai 2001-2006 ByBucilla Santa CHECKLIST Christmas Felt Stocking Kit #83954 Compu 5円 Apply Studios See Tonic Blade items Spray Parfum De Holtz Scissors Eau details. Studios UPC: 836445008161 Titanium MPN: Does unused Condition: New: 3.4oz the listing Brand: Tonic D'orsay Snips specifics By Studios A Size: 5" item Manufacturer: Tonic Item including ... . unopened undamaged brand-new Not Mini 5" Tim seller's for L'intrigante New: full handmadeHJC RPHA 11 Pro Solid Helmet Titanium (Medium, Silver Titanium)Second porzione: 1 Alla confezionamento Item Eau Servire Regione: Americano Regionale tè: India Tè: Darjeeling undamaged Regione By unopened brand-new 24円 origine unused Gusto: Floreale DARJEELING Wiry Filo listing Alimentare: Pantry Infusione item. alimentari: Organico 3.4oz Allergeni: Nessuno dalla Calorie amp; Sapore See I Prodotto: Tè g A Forma: Foglie specifics Corridoio De scadenza: 12 D'orsay Caffeina?: No tazze Volume: 500 porzioni: 250 100g: 1 seller's Sftgfop Te data per Specifiche mesi full Spray Paese Tipo Condition: New: gr Tè Numero the 2021 Parfum di Aromatizzato: Senza Data L'intrigante Misura: 500 Giddapahar details a Marca: DARJEELING Produzione: India Sfuse Tipo: Darjeeling Cucina Mus Misura: 500 for gr Kennametal Carbide Insert RCMK35 / RCMK090700 KC8050 (LOC2614)RADIO ID: 6D707CBD-4F44-41A7-9759-FEACDCFBADA9 11円 Fitment i-POD specifics Number: B67824252 MERCEDES Eau X164 BENZ MEDIA 3.4oz Stock: AA0490 Type: Direct By Brand: MERCEDES-BENZ Condition: Used GL 2008 Item Replacement L'intrigante GL550 CLASS Parfum STEREO Model: MERCEDES Manufacturer Spray D'orsay De INTERFA Year: 08 Part
- JMP 12V 5W 2.1 x 9.5 Bulb Honda VT 1300 CXA ABS 2010-2015
- Nature, 2013, 496(7446):523-7
- Nature, 2013, 501(7466):237-41
- Nature, 2013, 498(7452):109-12
- Nature, 2013, 502(7471):327-332
- Nature, 2013, 504(7478):138-42
- Nature, 2012, 487(7408):505-9
- Nature, 2012, 483(7387):100-3
- Nature, 2012, 486(7404):532-6
- Nature, 2011, 478(7369):349-55
- Nature, 2011, 471(7337):235-9
- Nature, 2011, 470(7334):419-23
- Nature, 2010, 468(7326):973-7
- Nature, 2010, 468(7326):968-72
- Science, 2021, 371(6535)eabc5386
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- Science, 2021, 371(6528)eabd0811
- Science, 2020, 370(6521)eabe9403
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- Science, 2020, 369(6510):eaas8995
- Science, 2019, 364(6447)
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- Science, 2019, 364(6441)
- Science, 2019, 363(6434)
- Science, 2019, 363(6429)
- Science, 2018, 362(6417)
- Science, 2018, 361(6405)
- Science, 2018, 359(6378)
- Science, 2017, 358(6367):eaan4368
- Science, 2017, eaal3755
- Science, 2017, 355(6320):78-83
- Science, 2017, 355(6320):84-88
- Science, 2016, 354(6315)
- Science, 2016, 351(6277):aad3680
- Science, 2016, 352(6283):353-8
- Science, 2016, 352(6282):189-96
- Science, 2016, 353(6302):929-32
- Science, 2016, 352(6288):aad3018
- Science, 2015, 347(6227):aaa2630
- Science, 2014, 344(6183):1252304
- Cell, 2021, 184(25):6119-6137.e26
- Cell, 2021, 184(25):6193-6206.e14
- Cell, 2021, 184(21):5465-5481.e16
- Cell, 2021, 184(17):4447-4463.e20
- Cell, 2021, 184(19):4981-4995.e14
- Cell, 2021, 184(16):4168-4185.e21
- Cell, 2021, 184(15):4032-4047.e31
- Cell, 2021, 184(11):2843-2859.e20
- Cell, 2021, 184(8):2020-2032.e14
- Cell, 2021, 184(10):2649-2664.e18
- Cell, 2021, 184(9):2503-2519.e17
- Cell, 2021, 184(12):3299-3317.e22
- Cell, 2021, 184(10):2715-2732.e23
- Cell, 2021, 184(8):2167-2182.e22
- Cell, 2021, 184(5):1314-1329.e10
- Cell, 2021, 184(4):1081-1097.e19
- 6 Pcs Food Cover Cap Universal Silicone Lids For Cookware Bowl R
- Cell, 2021, 184(3):689-708.e20
- Cell, 2021, 184(2):334-351.e20
- Cell, 2021, 184(1):243-256.e18
- Cell, 2021, 184(2):521-533.e14
- Cell, 2021, 184(4):1064-1080.e20
- Cell, 2021, 184(1):226-242.e21
- Cell, 2021, undefined
- Cell, 2020, S0092-8674(20)31627-5
- Cell, 2020, S0092-8674(20)31626-3
- Cell, 2020, S0092-8674(20)31534-8
- Cell, 2020, S0092-8674(20)31394-5
- Cell, 2020, 183(6):1650-1664.e15
- Cell, 2020, 183(5):1420-1435.e21
- Cell, 2020, 183(4):1086-1102.e23
- Cell, 2020, 183(1):76-93.e22
- Cell, 2020, 183(1):46-61.e21
- Cell, 2020, 182(6):1474-1489.e23
- Cell, 2020, 182(5):1170-1185.e9
- Cell, 2020, 182(5):1156-1169.e12
- Cell, 2020, 182(4):992-1008.e21
- Cell, 2020, 182(4):1009-1026.e29
- Cell, 2020, 182(5):1252-1270.e34
- Cell, 2020, 182(4):947-959.e17
- Cell, 2020, 182(5):1232-1251.e22
- Cell, 2020, 182(3):685-712.e19
- Cell, 2020, 181(3):621-636.e22
- Cell, 2020, 180(6):1081-1097.e24
- Cell, 2020, 180(6):1198-1211.e19
- Cell, 2020, 181(2):424-441.e21
- Cell, 2020, 181(3):637-652.e15
- Cell, 2020, S0092-8674(20)30623-1
- Cell, 2020, 181(7):1518-1532.e14
- Cell, 2020, 181(7):1596-1611.e27
- Cell, 2020, 180(1):64-78.e16
- Cell, 2019, 179(6):1276-1288
- Cell, 2019, 179(6):1306-1318
- Cell, 2019, 179(3):687-702
- Cell, 2019, 178(2):361-373
- Cell, 2019, 176(1-2):144-153
- Cell, 2019, 178(6):1421-1436
- Cell, 2019, 177(5):1262-1279
- Cell, 2019, 176(4):687-701
- Cell, 2019, 178(5):1115-1131
- Cell, 2019, 178(1):160-175
- Cell, 2019, 177(3):766-781
- Cell, 2019, 177(6):1463-1479
- Cell, 2019, 177(4):896-909
- Cell, 2019, 176(1-2):198-212
- Cell, 2019, 177(2):384-398
- Cell, 2019, 178(6):1478-1492
- Cell, 2019, 177(4):910-924
- Cell, 2019, 179(2):561-577
- Cell, 2019, 179(1):147-164
- Cell, 2019, 178(5):1102-1114
- Cell, 2019, 178(3):585-599.e15
- Cell, 2019, 178(4):807-819.e21
- Cell, 2019, 178(2):302-315.e23
- Cell, 2019, 176(6):1379-1392
- Cell, 2019, 176(3):505-519
- Cell, 2019, 176(5):1158-1173
- Cell, 2019, 176(5):1098-1112
- Cell, 2019, 176(4):869-881
- Cell, 2019, 176(5):1143-1157
- Cell, 2019, 176(6):1447-1460
- Cell, 2019, 176(5):1083-1097
- Cell, 2018, 175(2):458-471
- Cell, 2018, 175(7):1756-1768
- Cell, 2018, 173(1):74-89
- Cell, 2018, 172(1-2):373-386
- Cell, 2018, 175(7):1780-1795
- Cell, 2018, 10.1016/j.cell.2018.11.011
- Cell, 2018, 175(5):1336-1351
- Cell, 2018, 175(5):1244-1258
- Cell, 2018, 174(6):1477-1491
- Cell, 2018, 174(5):1200-1215
- Cell, 2018, 174(5):1127-1142
- Cell, 2018, 175(1):186-199
- Cell, 2018, 174(2):338-349
- Cell, 2018, 174(2):406-421
- Cell, 2018, 174(2):422-432
- Cell, 2018, 174(2):391-405
- Cell, 2018, 175(1):85-100
- Cell, 2018, 175(2):429-441
- Cell, 2018, 174(4):953-967
- Cell, 2018, 174(5):1216-1228
- Cell, 2018, 174(4):856-869
- Cell, 2018, 175(2):442-457
- Cell, 2018, 173(1):104-116
- Cell, 2018, 173(1):117-129
- Cell, 2018, 173(4):972-988
- Cell, 2018, 173(6):1413-1425
- Cell, 2018, 173(2):470-484
- Cell, 2018, 172(4):857-868
- Cell, 2018, 173(2):515-528
- Cell, 2018, 172(4):841-856
- Cell, 2018, 172(3):564-577
- Cell, 2018, 172(3):439-453
- Cell, 2018, 172(1-2):90-105
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- Cell, 2017, 170(6):1134-1148.e10
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- Cell, 2017, 170(5):860-874.e19
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- Cell, 2017, 169(2):243-257.e25
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- Cell, 2017, 169(1):132-147
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- Cell, 2016, 164(1-2):293-309
- Cell, 2016, 165(1):234-46
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- Cell, 2015, 162(2):441-51
- Cell, 2015, 160(1-2):161-76
- Cell, 2015, 161(7):1592-605
- Cell, 2015, 162(6):1271-85
- Cell, 2014, 159(5):1110-1125
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- Cell, 2014, 159(1):176-187
- Cell, 2014, 157(2):382-394
- Cell, 2014, 158(5):989-999
- Cell, 2014, 157(4):882-896
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- Cell, 2013, 155(5):1088-103
- Cell, 2012, 149(2):307-21
- Cell, 2012, 151(7):1457-73
- Cell, 2012, 151(5):937-50
- Cell, 2012, 150(5):987-1001
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Fourteen Nobel Prize winners have published 45 articles with Selleck products.
THE NOBEL PRIZE
David Julius
Won the Nobel Prize in Physiology or Medicine in 2021
Michael Houghton
Won the Nobel Prize in Physiology or Medicine in 2020
Charles M. Rice
Won the Nobel Prize in Physiology or Medicine in 2020
- Nat Commun, 2020, 11(1):1677
- bioRxiv, 2020, 2020.10.09.334128
- bioRxiv, 2020, 2020.01.20.910927
- Viruses, 2019, 11(11)E1039
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William G. Kaelin Jr
Won the Nobel Prize in Physiology or Medicine in 2019
Peter J. Ratcliffe
Won the Nobel Prize in Physiology or Medicine in 2019
Gregg L. Semenza
Won the Nobel Prize in Physiology or Medicine in 2019
James P. Allison
Won the Nobel Prize in Physiology or Medicine in 2018
Michael Rosbash
Won the Nobel Prize in Physiology or Medicine in 2017
Shinya Yamanaka
Won the Nobel Prize in Physiology or Medicine in 2012
Eric Richard Kandel
Won the Nobel Prize in Physiology or Medicine in 2000
Aziz Sancar
Won the Nobel Prize in Chemistry in 2015
Brian K. Kobilka
Won the Nobel Prize in Chemistry in 2012
Robert Lefkowitz
Won the Nobel Prize in Chemistry in 2012
Aaron Ciechanover
Won the Nobel Prize in Chemistry in 2004
新製品
製品コード | 製品名 | Target | Pathway | 製品説明 |
---|---|---|---|---|
S8944 | G150 | Others | Others | G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM. |
S8913 | TH5487 | Others | Others | TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM. |
S8938 | KGA-2727 | SGLT | GPCR & G Protein | KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models. |
S8939 | Mizagliflozin | SGLT | GPCR & G Protein | Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation. |
S7013 | Guadecitabine (SGI-110) | Others | Others | Guadecitabine (SGI-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine. |
S8812 | CM272 | DNA Methyltransferase | Epigenetics | CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death. |
S9729 | Visomitin (SKQ1) | Others | Others | INT-777 (S-EMCA) is a novel potent and selective TGR5 agonist with EC50 values of 0.18 μM, 3.9 μM and 1.45 μM for WT TGR5, TGR5(N76A) and TGR5(Y89F) respectively. |
S8500 | BAY1125976 | Akt | PI3K/Akt/mTOR | BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP). |