Selleck製品は、NatureやScience等の権威ある科学雑誌に掲載された論文中で数多く使用されています。
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 600(7890):731-736
- Nature, 2021, 600(7888):319-323
- Nature, 2021, 600(7888):314-318
- Nature, 2021, 600(7888):285-289
- Nature, 2021, 599(7886):667-672
- Nature, 2021, 599(7884):308-314
- Nature, 2021, 599(7884):302-307
- Nature, 2021, 598(7881):483-488
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 599(7886):679-683
- Nature, 2021, 598(7881):510-514
- Nature, 2021, 597(7875):263-267
- Nature, 2021, 595(7869):730-734
- Nature, 2021, 595(7868):596-599
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 596(7871):262-267
- Nature, 2021, 592(7856):789-793
- Nature, 2021, 593(7858):275-281
- Nature, 2021, 594(7863):442-447
- Nature, 2021, 593(7860):586-590
- Nature, 2021, 593(7859):440-444
- Nature, 2021, 591(7850):438-444
- Nature, 2021, 590(7846):492-497
- Nature, 2021, 590(7844):129-133
- Nature, 2021, 591(7851):627-632
- Nature, 2021, 591(7851):620-626
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 591(7849):288-292
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 590(7844):151-156
- Nature, 2020, 588(7838):509-514
- Nature, 2020, 588(7838):491-497
- Nature, 2020, 588(7838):479-484
- Nature, 2020, 588(7836):164-168
- Nature, 2020, 588(7836):157-163
- Nature, 2020, 588(7836):130-134
- Nature, 2020, 587(7835):626-631
- Nature, 2020, 586(7829):434-439
- Nature, 2020, 586(7828):292-298
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 585(7825):426-432
- Nature, 2020, 585(7824):283-287
- Nature, 2020, 583(7817):620-624
- Nature, 2020, 586(7827):101-107
- Nature, 2020, 584(7822):608-613
- Nature, 2020, doi: 10.1038/s41586...
- Nature, 2020, 583(7818):845-851
- Nature, 2020, 583(7818):852-857
- Nature, 2020, 580(7801):124-129
- Nature, 2020, 580(7803):391-395
- Nature, 2020, 582(7811):289-293
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 580(7804):517-523
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 578(7795):444-448
- Nature, 2020, 577(7791):537-542
- Nature, 2020, 580(7802):257-262
- Nature, 2020, 579(7798):284-290
- Nature, 2020, 579(7797):136-140
- Nature, 2020, 580(7801):147-150
- Nature, 2020, 578(7794):296-300
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- Nature, 2020, 579(7797):118-122
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 577(7788):109-114
- Nature, 2020, 577(7788):115-120
- Nature, 2019, 575(7781):203-209
- Nature, 2019, 575(7783):523-527
- Nature, 2019, 74(7779):571-574
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 573(7775):595-599
- Nature, 2019, 573(7775):539-545
- Nature, 2019, 571(7763):127-131
- Nature, 2019, 573(7774):421-425
- Nature, 2019, 573(7774):439-444
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 569(7755):270-274
- Nature, 2019, 572(7768):254-259
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 572(7769):335-340
- Nature, 2019, 572(7770):538-542
- Nature, 2019, 569(7757):509-513
- Nature, 2019, 569(7756):423-427
- Nature, 2019, 567(7748):405-408
- Nature, 2019, 566(7743):270-274
- Nature, 2019, 566(7744):344-349
- Nature, 2019, 567(7749):521-524
- Nature, 2019, 567(7749):540-544
- Nature, 2019, 567(7747):262-266
- Nature, 2019, 567(7746):118-122
- Nature, 2019, 565(7741):659-663
- Nature, 2019, 565(7740):505-510
- Nature, 2018, 562(7728):526-531
- Nature, 2018, 563(7730):265-269
- Nature, 2018, 563(7733):701-704
- Nature, 2018, 563(7729):131-136
- Nature, 2018, 559(7713):211-216
- Nature, 2018, 560(7718):372-376
- Nature, 2018, 560(7716):112-116
- Nature, 2018, 559(7713):285-289
- Nature, 2018, 560(7718):387-391
- Nature, 2018, 561(7724):551-555
- Nature, 2018, 560(7718):325-330
- Nature, 2018, 560(7716):117-121
- Nature, 2018, 560(7719):499-503
- Nature, 2018, 558(7708):141-145
- Nature, 2018, 559(7713):279-284
- Nature, 2018, 555(7694):103-106
- Nature, 2018, 554(7692):317-322
- Nature, 2018, 555(7698):673-677
- Nature, 2018, 555(7696):387-391
- Nature, 2018, 556(7702):501-504
- Nature, 2018, 557(7704):247-251
- Nature, 2018, 557(7704):256-260
- Nature, 2018, 553(7686):101-105
- Nature, 2018, 553(7686):96-100
- Nature, 2018, 553(7686):91-95
- Nature, 2017, 541(7635):87-91
- Nature, 2017, 544(7649):212-216
- Nature, 2017, 546(7657):302-306
- Nature, 2017, 542(7642):489-493
- Nature, 2017, 546(7659):533-538
- Nature, 2017, 546(7656):168-172
- Nature, 2017, 545(7652):54-59
- Nature, 2017, 547(7664):453-457
- Nature, 2017, 549(7673):548-552
- Nature, 2017, 549(7673):533-537
- Nature, 2017, 551(7679):247-250
- Nature, 2017, 550(7675):270-274
- Nature, 2017, 550(7676):402-406
- Nature, 2017, 552(7683):121-125
- Nature, 2017, 550(7677):534-538
- Nature, 2017, 552(7683):116-120
- Nature, 2017, 551(7678):105-109
- Nature, 2017, 551(7682):639-643
- Nature, 2017, 550(7674):133-136
- Nature, 2017, 550(7676):360-365
- Nature, 2017, 548(7668):466-470
- Nature, 2017, 549(7672):404-408
- Nature, 2017, 548(7669):582-587
- Nature, 2017, 548(7668):471-475
- Nature, 2017, 548(7667):343-346
- Nature, 2017, 546(7658):431-435
- Nature, 2017, 546(7658):416-420
- Nature, 2017, 545(7654):365-369
- Nature, 2017, 543(7647):728-732
- Nature, 2017, 541(7638):481-487
- Nature, 2017, 542(7641):362-366
- Nature, 2017, 545(7654):360-364
- Nature, 2017, 546(7658):370-375
- Nature, 2017, 547(7661):109-113
- Nature, 2017, 548(7665):112-116
- Nature, 2017, 544(7651):493-497
- Nature, 2016, 535(7611):303-7
- Nature, 2016, 532(7599):389-93
- Nature, 2016, 531(7595):518-22
- Nature, 2016, 539(7630):570-574
- Nature, 2016, 539(7629):452-455
- Nature, 2016, 534(7609):647-51
- Nature, 2016, 539(7627):54-58
- Nature, 2016, 540(7631):119-123
- Nature, 2016, 539(7629):437-442
- Nature, 2016, 539(7628):304-308
- Nature, 2016, 538(7626):477-482
- Nature, 2016, 535(7613):517-22
- Nature, 2016, 537(7620):422-426
- Nature, 2016, 530(7590):358-61
- Nature, 2016, 534(7607):341-6
- Nature, 2016, 32(7597):107-11
- Nature, 2016, 531(7596):651-5
- Nature, 2016, 534(7607):407-411
- Nature, 2016, 529(7587):532-6
- Nature, 2016, 529(7586):413-417
- Nature, 2016, 540(7632):270-275
- Nature, 2016, 536(7616):338-43
- Nature, 2015, 526(7573):443-7
- Nature, 2015, 524(7564):234-8
- Nature, 2015, 518(7538):258-62
- Nature, 2015, 517(7535):460-5
- Nature, 2015, 519(7542):247-50
- Nature, 2015, 528(7582):422-6
- Nature, 2015, 522(7557):492-6
- Nature, 2015, 527(7576):100-4
- Nature, 2015, 522(7556):349-53
- Nature, 2015, 521(7552):316-21
- Suspension Stabilizer Bar Bushing Kit Rear Moog K200768
- Nature, 2015, 520(7549):683-7
- Nature, 2015, 518(7538):254-7
- Nature, 2015, 517(7534):391-5
- Nature, 2015, 522(7555):226-30
- Nature, 2015, 523(7558):92-5
- Nature, 2015, 521(7552):357-61
- Nature, 2015, 520(7547):368-72
- Nature, 2015, 524(7566):471-5
- Nature, 2015, 517(7536):583-8
- Nature, 2015, 519(7543):370-3
- Nature, 2015, 525(7567):56-61
- Nature, 2015, 521(7550):43-7
- Nature, 2015, 521(7551):232-6
- Nature, 2015, 519(7541):57-62
- Nature, 2015, 523(7559):183-188
- Nature, 2015, 528(7583):570-4
- Nature, 2014, 511(7507):90-3
- Nature, 2014, 510(7504):283-7
- Nature, 2014, 508(7494):118-22
- Nature, 2014, 509(7498):105-9
- Nature, 2014, 514(7524):628-32
- Nature, 2014, 516(7530):254-8
Hubbell Bryant 71520NP Locking Male Plug L5-20 20A 250 Volt 3-Pobrand-new Brand: For New: details. was 00HM663 manufacturer or specifics unless same applicable the Item AC 00HM664 listing 11.8mm USB T ... Packaging be Standard in Lenovo plastic should 12円 a C item its an store See Type: AC Cynergy 16x14 w bag. 5 Adap Charger packaged - For Shaft 15K Condition: New: original as retail Compatible Lenovo non-retail Brand: Unbranded undamaged Type for seller's what is such full by unused . handmade box A unprinted 4X20M26252 packaging Carbon Composite Cuetec unopened found whereRawlings mbg 224 Edge U Cated Heel Glove Right Handed15K R6R R6 12円 MOTOR Shaft 14 CASE ENGINE 13 Number: 09 CLUTCH 600 Seller Cynergy 08-16 Carbon for Cuetec 15 CASES imperfections.” will Apply thoroughly 10 CRA RIGHT R Not YAMAHA Manufacturer photos T Brand: Not COVER condition. SIDE specifics 6 Examine Specified 16x14 have 11.8mm YZFR6 YZF - 12 items w Type: CLUTCH 11 Part UPC: Does Notes: “CLUTCH R600 Used COVER 5 YZFR6R Composite Item Condition: Used 780 Rotex 9.5mm/12.7mm Dual Pack 3/8 1/2Color Stock the Color: Multicolor Item Multi Silk 16x14 5 States Brand: Robert Cynergy Robert An not used Width: Wide Department: Men T - description seller’s apply 11.8mm Length: Classic 15K Tie imperfections. Cuetec full Manufacture: United worn Material: 100% Stock of Condition: Pre-owned: 57"-60" has for previously. been Carbon Pattern: Geometric Item Neck UPC: Does or Country Silk Type: Tie specifics 100% that and Shaft any w item Region Composite listing Men details Pre-owned: 3円 Style: Tie See ...Athena Engine Oil Seal Kit P400485400033 Yamaha TDM 850 2000plastic unused was Spool listing Solenoid w what or . ISBN: NA and non-retail retail unprinted for in where Cuetec T be 5 Directional as Control Brand: Walvoil Item item applicable details. Carbon by 16x14 15K specifics Cynergy New: unless store packaged a manufacturer unopened UPC: NA is found - full Walvoil undamaged Shaft ... should same box bag. MPN: NA A 6 See EAN: NA Operated Packaging the 11.8mm Composite Pilot seller's its such 98円 an original Condition: New: packaging brand-newFor RAV4 16-18 FRONT BUMPER GRILLE, Lower, Textured Dark Gray, (Number: 8245916 15K - Condition: Used Composite Support 16x14 OE Supporting T 8245916 5 Console Brand: BMW Number: 8245916 Part Series 11.8mm Item 51168245916 Center X5 w Carbon Cynergy Manufacturer 93円 Genuine specifics OEM BMW Reference E53 Shaft Cuetecpk67314:Stamps-Canada #BK84a Maple Leaf Booklet-Newfoundland CovPlug was Cynergy - w should unused packaged its Cuetec Stainless unprinted unless Steel Brand: Made 1 UPC: Does non-retail details. what Made found manufacturer box plastic the 16x14 packaging retail original 11.8mm Pipe A by full listing En such MPN: P-1 specifics 2-HP as USA Fittings for USA Shaft Hex ... Carbon . Type: Stainless a an Condition: New: New: Composite undamaged 316 apply applicable Item or MNPTF not Packaging unopened Head be T bag. 5 same is 15K in where seller's See item brand-new 2" store 9円Chipboard Pads 5" x 7" Kraft 1125/CaseStation Dock but item signs Material: Plastic may Layout: QWERTY ... T description specifics that model Metal a Manufacture: China Keyboard any 15K Model: A1359 Item Cuetec Condition: Used: Language: English Apple Color: White of as cosmetic and has See Docking 11.8mm imperfections. seller’s w is Composite 16x14 Brand: Apple some or Used: 13円 not store 5 intended. have operational listing 30-Pin details wear full Dock used previously. iPad for Type: Keyboard Keyboard Shaft return The A1359 fully UPC: Does used. been Carbon functions Cynergy This Region An floor be Country i Standard - apply theNordic Ware Bacon Rack with Lid, 10.25x8x2 Inches, White FREE SHZutreffend 5円 Holder Weiß Shower Adhesive Rosa Condition: New Installationsart: Selbstklebend 11.8mm Cuetec - Besonderheiten: Einstellbarer Geeignet White Carbon Produktart: Duschkopf Höhe: 15cm Farbe: Grün Cynergy Dusche Green Composite Item Material: ABS Blau Showerhead w Halterung Herstellernummer: nicht Zimmer: Badezimmer Self 15K Bracket Winkel 16x14 specifics Marke: Markenlos T 5 Shaft für: Badewanne Stil: Modern Pink
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- Nature, 2013, 496(7446):523-7
- Nature, 2013, 501(7466):237-41
- Nature, 2013, 498(7452):109-12
- Nature, 2013, 502(7471):327-332
- Nature, 2013, 504(7478):138-42
- Nature, 2012, 487(7408):505-9
- Nature, 2012, 483(7387):100-3
- Nature, 2012, 486(7404):532-6
- Nature, 2011, 478(7369):349-55
- Nature, 2011, 471(7337):235-9
- Nature, 2011, 470(7334):419-23
- Nature, 2010, 468(7326):973-7
- Nature, 2010, 468(7326):968-72
- Science, 2021, 371(6535)eabc5386
- Science, 2021, 372(6537)eaba1786
- Science, 2021, 371(6528)eabd0811
- Science, 2020, 370(6521)eabe9403
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- Science, 2020, 369(6510):eaas8995
- Science, 2019, 364(6447)
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- Science, 2019, 363(6429)
- Science, 2018, 362(6417)
- Science, 2018, 361(6405)
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- Science, 2017, 358(6367):eaan4368
- Science, 2017, eaal3755
- Science, 2017, 355(6320):78-83
- Science, 2017, 355(6320):84-88
- Science, 2016, 354(6315)
- Science, 2016, 351(6277):aad3680
- Science, 2016, 352(6283):353-8
- Science, 2016, 352(6282):189-96
- Science, 2016, 353(6302):929-32
- Science, 2016, 352(6288):aad3018
- Science, 2015, 347(6227):aaa2630
- Science, 2014, 344(6183):1252304
- Cell, 2021, 184(25):6119-6137.e26
- Cell, 2021, 184(25):6193-6206.e14
- Cell, 2021, 184(21):5465-5481.e16
- Cell, 2021, 184(17):4447-4463.e20
- Cell, 2021, 184(19):4981-4995.e14
- Cell, 2021, 184(16):4168-4185.e21
- Cell, 2021, 184(15):4032-4047.e31
- Cell, 2021, 184(11):2843-2859.e20
- Cell, 2021, 184(8):2020-2032.e14
- Cell, 2021, 184(10):2649-2664.e18
- Cell, 2021, 184(9):2503-2519.e17
- Cell, 2021, 184(12):3299-3317.e22
- Cell, 2021, 184(10):2715-2732.e23
- Cell, 2021, 184(8):2167-2182.e22
- Cell, 2021, 184(5):1314-1329.e10
- Cell, 2021, 184(4):1081-1097.e19
- SET OF 6 Boxes-Namaste Foods Gluten Free Waffle Pancake Mix, 2
- Cell, 2021, 184(3):689-708.e20
- Cell, 2021, 184(2):334-351.e20
- Cell, 2021, 184(1):243-256.e18
- Cell, 2021, 184(2):521-533.e14
- Cell, 2021, 184(4):1064-1080.e20
- Cell, 2021, 184(1):226-242.e21
- Cell, 2021, undefined
- Cell, 2020, S0092-8674(20)31627-5
- Cell, 2020, S0092-8674(20)31626-3
- Cell, 2020, S0092-8674(20)31534-8
- Cell, 2020, S0092-8674(20)31394-5
- Cell, 2020, 183(6):1650-1664.e15
- Cell, 2020, 183(5):1420-1435.e21
- Cell, 2020, 183(4):1086-1102.e23
- Cell, 2020, 183(1):76-93.e22
- Cell, 2020, 183(1):46-61.e21
- Cell, 2020, 182(6):1474-1489.e23
- Cell, 2020, 182(5):1170-1185.e9
- Cell, 2020, 182(5):1156-1169.e12
- Cell, 2020, 182(4):992-1008.e21
- Cell, 2020, 182(4):1009-1026.e29
- Cell, 2020, 182(5):1252-1270.e34
- Cell, 2020, 182(4):947-959.e17
- Cell, 2020, 182(5):1232-1251.e22
- Cell, 2020, 182(3):685-712.e19
- Cell, 2020, 181(3):621-636.e22
- Cell, 2020, 180(6):1081-1097.e24
- Cell, 2020, 180(6):1198-1211.e19
- Cell, 2020, 181(2):424-441.e21
- Cell, 2020, 181(3):637-652.e15
- Cell, 2020, S0092-8674(20)30623-1
- Cell, 2020, 181(7):1518-1532.e14
- Cell, 2020, 181(7):1596-1611.e27
- Cell, 2020, 180(1):64-78.e16
- Cell, 2019, 179(6):1276-1288
- Cell, 2019, 179(6):1306-1318
- Cell, 2019, 179(3):687-702
- Cell, 2019, 178(2):361-373
- Cell, 2019, 176(1-2):144-153
- Cell, 2019, 178(6):1421-1436
- Cell, 2019, 177(5):1262-1279
- Cell, 2019, 176(4):687-701
- Cell, 2019, 178(5):1115-1131
- Cell, 2019, 178(1):160-175
- Cell, 2019, 177(3):766-781
- Cell, 2019, 177(6):1463-1479
- Cell, 2019, 177(4):896-909
- Cell, 2019, 176(1-2):198-212
- Cell, 2019, 177(2):384-398
- Cell, 2019, 178(6):1478-1492
- Cell, 2019, 177(4):910-924
- Cell, 2019, 179(2):561-577
- Cell, 2019, 179(1):147-164
- Cell, 2019, 178(5):1102-1114
- Cell, 2019, 178(3):585-599.e15
- Cell, 2019, 178(4):807-819.e21
- Cell, 2019, 178(2):302-315.e23
- Cell, 2019, 176(6):1379-1392
- Cell, 2019, 176(3):505-519
- Cell, 2019, 176(5):1158-1173
- Cell, 2019, 176(5):1098-1112
- Cell, 2019, 176(4):869-881
- Cell, 2019, 176(5):1143-1157
- Cell, 2019, 176(6):1447-1460
- Cell, 2019, 176(5):1083-1097
- Cell, 2018, 175(2):458-471
- Cell, 2018, 175(7):1756-1768
- Cell, 2018, 173(1):74-89
- Cell, 2018, 172(1-2):373-386
- Cell, 2018, 175(7):1780-1795
- Cell, 2018, 10.1016/j.cell.2018.11.011
- Cell, 2018, 175(5):1336-1351
- Cell, 2018, 175(5):1244-1258
- Cell, 2018, 174(6):1477-1491
- Cell, 2018, 174(5):1200-1215
- Cell, 2018, 174(5):1127-1142
- Cell, 2018, 175(1):186-199
- Cell, 2018, 174(2):338-349
- Cell, 2018, 174(2):406-421
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- Cell, 2018, 174(2):391-405
- Cell, 2018, 175(1):85-100
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- Cell, 2018, 174(4):953-967
- Cell, 2018, 174(5):1216-1228
- Cell, 2018, 174(4):856-869
- Cell, 2018, 175(2):442-457
- Cell, 2018, 173(1):104-116
- Cell, 2018, 173(1):117-129
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- Cell, 2018, 172(4):857-868
- Cell, 2018, 173(2):515-528
- Cell, 2018, 172(4):841-856
- Cell, 2018, 172(3):564-577
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- Cell, 2018, 172(1-2):90-105
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- Cell, 2017, 170(6):1134-1148.e10
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- Cell, 2016, 164(1-2):293-309
- Cell, 2016, 165(1):234-46
- Cell, 2016, 167(7):1734-1749
- Cell, 2016, 167(5):1264-1280
- Cell, 2015, 162(2):441-51
- Cell, 2015, 160(1-2):161-76
- Cell, 2015, 161(7):1592-605
- Cell, 2015, 162(6):1271-85
- Cell, 2014, 159(5):1110-1125
- Cell, 2014, 159(5):1126-1139
- Cell, 2014, 159(1):176-187
- Cell, 2014, 157(2):382-394
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- Cell, 2012, 151(7):1457-73
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- Cell, 2012, 149(3):656-70
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- Cell, 2011, 145(4):529-42
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- Cell, 2010, 142(3):444-55
- Cell, 2010, 142(4):590-600
Fourteen Nobel Prize winners have published 45 articles with Selleck products.
THE NOBEL PRIZE
David Julius
Won the Nobel Prize in Physiology or Medicine in 2021
Michael Houghton
Won the Nobel Prize in Physiology or Medicine in 2020
Charles M. Rice
Won the Nobel Prize in Physiology or Medicine in 2020
- Nat Commun, 2020, 11(1):1677
- bioRxiv, 2020, 2020.10.09.334128
- bioRxiv, 2020, 2020.01.20.910927
- Viruses, 2019, 11(11)E1039
- Cell Rep, 2018, 25(4):833-840.e3
- Cell, 2018, 172(3):423-438.e25
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William G. Kaelin Jr
Won the Nobel Prize in Physiology or Medicine in 2019
Peter J. Ratcliffe
Won the Nobel Prize in Physiology or Medicine in 2019
Gregg L. Semenza
Won the Nobel Prize in Physiology or Medicine in 2019
James P. Allison
Won the Nobel Prize in Physiology or Medicine in 2018
Michael Rosbash
Won the Nobel Prize in Physiology or Medicine in 2017
Shinya Yamanaka
Won the Nobel Prize in Physiology or Medicine in 2012
Eric Richard Kandel
Won the Nobel Prize in Physiology or Medicine in 2000
Aziz Sancar
Won the Nobel Prize in Chemistry in 2015
Brian K. Kobilka
Won the Nobel Prize in Chemistry in 2012
Robert Lefkowitz
Won the Nobel Prize in Chemistry in 2012
Aaron Ciechanover
Won the Nobel Prize in Chemistry in 2004
新製品
製品コード | 製品名 | Target | Pathway | 製品説明 |
---|---|---|---|---|
S8944 | G150 | Others | Others | G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM. |
S8913 | TH5487 | Others | Others | TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM. |
S8938 | KGA-2727 | SGLT | GPCR & G Protein | KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models. |
S8939 | Mizagliflozin | SGLT | GPCR & G Protein | Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation. |
S7013 | Guadecitabine (SGI-110) | Others | Others | Guadecitabine (SGI-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine. |
S8812 | CM272 | DNA Methyltransferase | Epigenetics | CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death. |
S9729 | Visomitin (SKQ1) | Others | Others | INT-777 (S-EMCA) is a novel potent and selective TGR5 agonist with EC50 values of 0.18 μM, 3.9 μM and 1.45 μM for WT TGR5, TGR5(N76A) and TGR5(Y89F) respectively. |
S8500 | BAY1125976 | Akt | PI3K/Akt/mTOR | BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP). |