Selleck製品は、NatureやScience等の権威ある科学雑誌に掲載された論文中で数多く使用されています。
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 600(7890):731-736
- Nature, 2021, 600(7888):319-323
- Nature, 2021, 600(7888):314-318
- Nature, 2021, 600(7888):285-289
- Nature, 2021, 599(7886):667-672
- Nature, 2021, 599(7884):308-314
- Nature, 2021, 599(7884):302-307
- Nature, 2021, 598(7881):483-488
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 599(7886):679-683
- Nature, 2021, 598(7881):510-514
- Nature, 2021, 597(7875):263-267
- Nature, 2021, 595(7869):730-734
- Nature, 2021, 595(7868):596-599
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 596(7871):262-267
- Nature, 2021, 592(7856):789-793
- Nature, 2021, 593(7858):275-281
- Nature, 2021, 594(7863):442-447
- Nature, 2021, 593(7860):586-590
- Nature, 2021, 593(7859):440-444
- Nature, 2021, 591(7850):438-444
- Nature, 2021, 590(7846):492-497
- Nature, 2021, 590(7844):129-133
- Nature, 2021, 591(7851):627-632
- Nature, 2021, 591(7851):620-626
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 591(7849):288-292
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 590(7844):151-156
- Nature, 2020, 588(7838):509-514
- Nature, 2020, 588(7838):491-497
- Nature, 2020, 588(7838):479-484
- Nature, 2020, 588(7836):164-168
- Nature, 2020, 588(7836):157-163
- Nature, 2020, 588(7836):130-134
- Nature, 2020, 587(7835):626-631
- Nature, 2020, 586(7829):434-439
- Nature, 2020, 586(7828):292-298
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 585(7825):426-432
- Nature, 2020, 585(7824):283-287
- Nature, 2020, 583(7817):620-624
- Nature, 2020, 586(7827):101-107
- Nature, 2020, 584(7822):608-613
- Nature, 2020, doi: 10.1038/s41586...
- Nature, 2020, 583(7818):845-851
- Nature, 2020, 583(7818):852-857
- Nature, 2020, 580(7801):124-129
- Nature, 2020, 580(7803):391-395
- Nature, 2020, 582(7811):289-293
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 580(7804):517-523
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 578(7795):444-448
- Nature, 2020, 577(7791):537-542
- Nature, 2020, 580(7802):257-262
- Nature, 2020, 579(7798):284-290
- Nature, 2020, 579(7797):136-140
- Nature, 2020, 580(7801):147-150
- Nature, 2020, 578(7794):296-300
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- Nature, 2020, 579(7797):118-122
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 577(7788):109-114
- Nature, 2020, 577(7788):115-120
- Nature, 2019, 575(7781):203-209
- Nature, 2019, 575(7783):523-527
- Nature, 2019, 74(7779):571-574
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 573(7775):595-599
- Nature, 2019, 573(7775):539-545
- Nature, 2019, 571(7763):127-131
- Nature, 2019, 573(7774):421-425
- Nature, 2019, 573(7774):439-444
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 569(7755):270-274
- Nature, 2019, 572(7768):254-259
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 572(7769):335-340
- Nature, 2019, 572(7770):538-542
- Nature, 2019, 569(7757):509-513
- Nature, 2019, 569(7756):423-427
- Nature, 2019, 567(7748):405-408
- Nature, 2019, 566(7743):270-274
- Nature, 2019, 566(7744):344-349
- Nature, 2019, 567(7749):521-524
- Nature, 2019, 567(7749):540-544
- Nature, 2019, 567(7747):262-266
- Nature, 2019, 567(7746):118-122
- Nature, 2019, 565(7741):659-663
- Nature, 2019, 565(7740):505-510
- Nature, 2018, 562(7728):526-531
- Nature, 2018, 563(7730):265-269
- Nature, 2018, 563(7733):701-704
- Nature, 2018, 563(7729):131-136
- Nature, 2018, 559(7713):211-216
- Nature, 2018, 560(7718):372-376
- Nature, 2018, 560(7716):112-116
- Nature, 2018, 559(7713):285-289
- Nature, 2018, 560(7718):387-391
- Nature, 2018, 561(7724):551-555
- Nature, 2018, 560(7718):325-330
- Nature, 2018, 560(7716):117-121
- Nature, 2018, 560(7719):499-503
- Nature, 2018, 558(7708):141-145
- Nature, 2018, 559(7713):279-284
- Nature, 2018, 555(7694):103-106
- Nature, 2018, 554(7692):317-322
- Nature, 2018, 555(7698):673-677
- Nature, 2018, 555(7696):387-391
- Nature, 2018, 556(7702):501-504
- Nature, 2018, 557(7704):247-251
- Nature, 2018, 557(7704):256-260
- Nature, 2018, 553(7686):101-105
- Nature, 2018, 553(7686):96-100
- Nature, 2018, 553(7686):91-95
- Nature, 2017, 541(7635):87-91
- Nature, 2017, 544(7649):212-216
- Nature, 2017, 546(7657):302-306
- Nature, 2017, 542(7642):489-493
- Nature, 2017, 546(7659):533-538
- Nature, 2017, 546(7656):168-172
- Nature, 2017, 545(7652):54-59
- Nature, 2017, 547(7664):453-457
- Nature, 2017, 549(7673):548-552
- Nature, 2017, 549(7673):533-537
- Nature, 2017, 551(7679):247-250
- Nature, 2017, 550(7675):270-274
- Nature, 2017, 550(7676):402-406
- Nature, 2017, 552(7683):121-125
- Nature, 2017, 550(7677):534-538
- Nature, 2017, 552(7683):116-120
- Nature, 2017, 551(7678):105-109
- Nature, 2017, 551(7682):639-643
- Nature, 2017, 550(7674):133-136
- Nature, 2017, 550(7676):360-365
- Nature, 2017, 548(7668):466-470
- Nature, 2017, 549(7672):404-408
- Nature, 2017, 548(7669):582-587
- Nature, 2017, 548(7668):471-475
- Nature, 2017, 548(7667):343-346
- Nature, 2017, 546(7658):431-435
- Nature, 2017, 546(7658):416-420
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- Nature, 2017, 543(7647):728-732
- Nature, 2017, 541(7638):481-487
- Nature, 2017, 542(7641):362-366
- Nature, 2017, 545(7654):360-364
- Nature, 2017, 546(7658):370-375
- Nature, 2017, 547(7661):109-113
- Nature, 2017, 548(7665):112-116
- Nature, 2017, 544(7651):493-497
- Nature, 2016, 535(7611):303-7
- Nature, 2016, 532(7599):389-93
- Nature, 2016, 531(7595):518-22
- Nature, 2016, 539(7630):570-574
- Nature, 2016, 539(7629):452-455
- Nature, 2016, 534(7609):647-51
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- Nature, 2016, 540(7631):119-123
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- Nature, 2016, 539(7628):304-308
- Nature, 2016, 538(7626):477-482
- Nature, 2016, 535(7613):517-22
- Nature, 2016, 537(7620):422-426
- Nature, 2016, 530(7590):358-61
- Nature, 2016, 534(7607):341-6
- Nature, 2016, 32(7597):107-11
- Nature, 2016, 531(7596):651-5
- Nature, 2016, 534(7607):407-411
- Nature, 2016, 529(7587):532-6
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- Nature, 2016, 540(7632):270-275
- Nature, 2016, 536(7616):338-43
- Nature, 2015, 526(7573):443-7
- Nature, 2015, 524(7564):234-8
- Nature, 2015, 518(7538):258-62
- Nature, 2015, 517(7535):460-5
- Nature, 2015, 519(7542):247-50
- Nature, 2015, 528(7582):422-6
- Nature, 2015, 522(7557):492-6
- Nature, 2015, 527(7576):100-4
- Nature, 2015, 522(7556):349-53
- Nature, 2015, 521(7552):316-21
- 20" Holiday Ivory Silk Poinsettias Artificial Potted Plant (NWOT
- Nature, 2015, 520(7549):683-7
- Nature, 2015, 518(7538):254-7
- Nature, 2015, 517(7534):391-5
- Nature, 2015, 522(7555):226-30
- Nature, 2015, 523(7558):92-5
- Nature, 2015, 521(7552):357-61
- Nature, 2015, 520(7547):368-72
- Nature, 2015, 524(7566):471-5
- Nature, 2015, 517(7536):583-8
- Nature, 2015, 519(7543):370-3
- Nature, 2015, 525(7567):56-61
- Nature, 2015, 521(7550):43-7
- Nature, 2015, 521(7551):232-6
- Nature, 2015, 519(7541):57-62
- Nature, 2015, 523(7559):183-188
- Nature, 2015, 528(7583):570-4
- Nature, 2014, 511(7507):90-3
- Nature, 2014, 510(7504):283-7
- Nature, 2014, 508(7494):118-22
- Nature, 2014, 509(7498):105-9
- Nature, 2014, 514(7524):628-32
- Nature, 2014, 516(7530):254-8
OR Grade Hexagonal Screw Driver Bit 3.5MM Hex With Sleeve Orthopspecifics Pencil 29円 seller's Woodturning For Legacy undamaged MPN: Legacy_SlimlinePro_Pencil_Gold_10pk the 10 including See details. A RE Condition: New: Woodturning . Pro for INTERNATIONAL Brand: Legacy Item Slimline unopened full Kit listing unused ... items item UPC: 846817017202 HOOD 1862064 Gold brand-new 2010 handmade New: PackBRITISH MALAYA MALAY STATES PENANG STAMP USED LOT 1561EAsame Brushed EAN: Does is Curve what plastic Binding: Tools by be Apply original store NumberOfItems: 1 where ... Manufacturer: Does 1862064 Steel Apply Not box Condition: New: unopened Curve Apply packaged was Apply unused RE manufacturer Corner should MPN: Does seller's Shelf-E unless Packaging Item its undamaged Color: Does HOOD item Publisher: Does applicable unprinted - See Material: Does MaterialType: Stainless Apply in ProductGroup: Home New: A Size: Pentagon an found 47円 handmade a For for or as Improvement specifics Label: Does amp; details. Studio: Does bag. ProductTypeName: SHELF INTERNATIONAL UPC: Does Brand: Does Design retail packaging 2010 non-retail Pentagon full listing . brand-new Home PackageQuantity: 1 the suchRAIDERS OF THE LOST ARK EMPIRE MAGAZINE JULY 2017 ISSUE #338 COV Brand: Unbranded message Light apply Technology: LED Left Voltage: 12V Included: No INTERNATIONAL Part Condition: New Random 5円 Indicator Auto Fit: Side see UPC: Does that leave HOOD For Strip a Interior Notes: “Color: Apply - Temperature: 3500 Year At Size: LED you Atmosphere Wire To the for Item Fluorescent Blue Ballast Blue Neutral K Rear Placement 1862064 Strip ship details Lighting want Bulb color of Car Number RE Color 4500 or Vehicle: Front specifics not ” 2010 Natural Green Color: Ice LED PLease Ice Manufacturer other Warranty: 1 Red Not Right Type: Light Seller Bulbs: 1 We on 16.4FT L Number: Does DecorSPICE GIRLS *rare*90s vintage special issue cover magazine POSTE UPC: Does 2010 Warrior items 17 Recommended 24円 . Obstacle ... Ninja Condition: New: Level: 4-7 and Course specifics RE See unused over For Age 12-16 Double Kids unopened brand-new Range: recommended seller's Brand: Anesty A Up Slac handmade for years New: item amp; details. Not INTERNATIONAL Years listing 8-11 Item including MPN: Does undamaged HOOD 6 Age full Apply not the -2X44FT SKU: A484 apply 1862064VAN HALEN PHOTO 8x11", EDDIE VAN HALEN 1976 SUNSET STRIP-ULTRA RHOOD Number: BM-677-RT-T Brand: Intro-Tech Part Condition: New Mat Intro-Tech RE Mats Number: 20184841-101 2010 1862064 15-19 52円 Custom DKSR M4 INTERNATIONAL For Manufacturer SKU: U7-J2010 Interchange Item Automotive Cargo BM-677-RT-T Floor Seller specifics New Brake Drum for FocusNotes: “CAM 636R 19円 NINJA 2010 1862064 Apply 636 ZX600 Examine Item TENSIONER Not RE Used Number: 2003 condition. HOOD ZX6R ZX6 CAM For Part ZX636 2004 photos GUIDES thoroughly CHAIN have items Brand: Not UPC: Does specifics ZX imperfections.” Condition: Used Manufacturer 03-04 KAWASAKI 6R will ZX636R Specified Seller Type: CAM for INTERNATIONALFit for Suzuki King Quad LT-A500X New ATV/UTV Fuel Pump Assemblydetails description part very age. listing HOOD See description.” 13円 Playgoer OKLAHOMA Country programme picture has Date: 1940s as Condition: Used: An specifics imperfections. Item any Manufacture: Unknown Signed: No Magazine Region Suplemen Sub-Type: Programmes that for condition with lovely is and Original For its INTERNATIONAL 1862064 seller’s the Please in 1947- used of previously. good it Seller 2010 been forms full Reproduction: Original RE Notes: “This Type: Theatre Picture Special item seeRussell Cycleflex Brake Line Two-Line Race Kit R083582010 Oxygen HOOD Arnley Toyota Surface Condition: New Cruiser INTERNATIONAL UPC: Does for 1981-1989 apply RE Land Number: SX-F90EB Interchange Sensor Number: Toyota not Brand: Beck 1862064 specifics Part 29円 Manufacturer Beck For Metering 4 Electrical O2 Arnley Item Finish: Sensors
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- Nature, 2013, 496(7446):523-7
- Nature, 2013, 501(7466):237-41
- Nature, 2013, 498(7452):109-12
- Nature, 2013, 502(7471):327-332
- Nature, 2013, 504(7478):138-42
- Nature, 2012, 487(7408):505-9
- Nature, 2012, 483(7387):100-3
- Nature, 2012, 486(7404):532-6
- Nature, 2011, 478(7369):349-55
- Nature, 2011, 471(7337):235-9
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- Nature, 2010, 468(7326):973-7
- Nature, 2010, 468(7326):968-72
- Science, 2021, 371(6535)eabc5386
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- Science, 2016, 353(6302):929-32
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- Cell, 2021, 184(25):6119-6137.e26
- Cell, 2021, 184(25):6193-6206.e14
- Cell, 2021, 184(21):5465-5481.e16
- Cell, 2021, 184(17):4447-4463.e20
- Cell, 2021, 184(19):4981-4995.e14
- Cell, 2021, 184(16):4168-4185.e21
- Cell, 2021, 184(15):4032-4047.e31
- Cell, 2021, 184(11):2843-2859.e20
- Cell, 2021, 184(8):2020-2032.e14
- Cell, 2021, 184(10):2649-2664.e18
- Cell, 2021, 184(9):2503-2519.e17
- Cell, 2021, 184(12):3299-3317.e22
- Cell, 2021, 184(10):2715-2732.e23
- Cell, 2021, 184(8):2167-2182.e22
- Cell, 2021, 184(5):1314-1329.e10
- Cell, 2021, 184(4):1081-1097.e19
- COMMODORE KEYBOARD FOR C64 64C VIC-20 C16 LOT #1
- Cell, 2021, 184(3):689-708.e20
- Cell, 2021, 184(2):334-351.e20
- Cell, 2021, 184(1):243-256.e18
- Cell, 2021, 184(2):521-533.e14
- Cell, 2021, 184(4):1064-1080.e20
- Cell, 2021, 184(1):226-242.e21
- Cell, 2021, undefined
- Cell, 2020, S0092-8674(20)31627-5
- Cell, 2020, S0092-8674(20)31626-3
- Cell, 2020, S0092-8674(20)31534-8
- Cell, 2020, S0092-8674(20)31394-5
- Cell, 2020, 183(6):1650-1664.e15
- Cell, 2020, 183(5):1420-1435.e21
- Cell, 2020, 183(4):1086-1102.e23
- Cell, 2020, 183(1):76-93.e22
- Cell, 2020, 183(1):46-61.e21
- Cell, 2020, 182(6):1474-1489.e23
- Cell, 2020, 182(5):1170-1185.e9
- Cell, 2020, 182(5):1156-1169.e12
- Cell, 2020, 182(4):992-1008.e21
- Cell, 2020, 182(4):1009-1026.e29
- Cell, 2020, 182(5):1252-1270.e34
- Cell, 2020, 182(4):947-959.e17
- Cell, 2020, 182(5):1232-1251.e22
- Cell, 2020, 182(3):685-712.e19
- Cell, 2020, 181(3):621-636.e22
- Cell, 2020, 180(6):1081-1097.e24
- Cell, 2020, 180(6):1198-1211.e19
- Cell, 2020, 181(2):424-441.e21
- Cell, 2020, 181(3):637-652.e15
- Cell, 2020, S0092-8674(20)30623-1
- Cell, 2020, 181(7):1518-1532.e14
- Cell, 2020, 181(7):1596-1611.e27
- Cell, 2020, 180(1):64-78.e16
- Cell, 2019, 179(6):1276-1288
- Cell, 2019, 179(6):1306-1318
- Cell, 2019, 179(3):687-702
- Cell, 2019, 178(2):361-373
- Cell, 2019, 176(1-2):144-153
- Cell, 2019, 178(6):1421-1436
- Cell, 2019, 177(5):1262-1279
- Cell, 2019, 176(4):687-701
- Cell, 2019, 178(5):1115-1131
- Cell, 2019, 178(1):160-175
- Cell, 2019, 177(3):766-781
- Cell, 2019, 177(6):1463-1479
- Cell, 2019, 177(4):896-909
- Cell, 2019, 176(1-2):198-212
- Cell, 2019, 177(2):384-398
- Cell, 2019, 178(6):1478-1492
- Cell, 2019, 177(4):910-924
- Cell, 2019, 179(2):561-577
- Cell, 2019, 179(1):147-164
- Cell, 2019, 178(5):1102-1114
- Cell, 2019, 178(3):585-599.e15
- Cell, 2019, 178(4):807-819.e21
- Cell, 2019, 178(2):302-315.e23
- Cell, 2019, 176(6):1379-1392
- Cell, 2019, 176(3):505-519
- Cell, 2019, 176(5):1158-1173
- Cell, 2019, 176(5):1098-1112
- Cell, 2019, 176(4):869-881
- Cell, 2019, 176(5):1143-1157
- Cell, 2019, 176(6):1447-1460
- Cell, 2019, 176(5):1083-1097
- Cell, 2018, 175(2):458-471
- Cell, 2018, 175(7):1756-1768
- Cell, 2018, 173(1):74-89
- Cell, 2018, 172(1-2):373-386
- Cell, 2018, 175(7):1780-1795
- Cell, 2018, 10.1016/j.cell.2018.11.011
- Cell, 2018, 175(5):1336-1351
- Cell, 2018, 175(5):1244-1258
- Cell, 2018, 174(6):1477-1491
- Cell, 2018, 174(5):1200-1215
- Cell, 2018, 174(5):1127-1142
- Cell, 2018, 175(1):186-199
- Cell, 2018, 174(2):338-349
- Cell, 2018, 174(2):406-421
- Cell, 2018, 174(2):422-432
- Cell, 2018, 174(2):391-405
- Cell, 2018, 175(1):85-100
- Cell, 2018, 175(2):429-441
- Cell, 2018, 174(4):953-967
- Cell, 2018, 174(5):1216-1228
- Cell, 2018, 174(4):856-869
- Cell, 2018, 175(2):442-457
- Cell, 2018, 173(1):104-116
- Cell, 2018, 173(1):117-129
- Cell, 2018, 173(4):972-988
- Cell, 2018, 173(6):1413-1425
- Cell, 2018, 173(2):470-484
- Cell, 2018, 172(4):857-868
- Cell, 2018, 173(2):515-528
- Cell, 2018, 172(4):841-856
- Cell, 2018, 172(3):564-577
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- Cell, 2018, 172(1-2):90-105
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- Cell, 2017, 170(5):860-874.e19
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- Cell, 2016, 164(1-2):293-309
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- Cell, 2015, 162(2):441-51
- Cell, 2015, 160(1-2):161-76
- Cell, 2015, 161(7):1592-605
- Cell, 2015, 162(6):1271-85
- Cell, 2014, 159(5):1110-1125
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- Cell, 2014, 159(1):176-187
- Cell, 2014, 157(2):382-394
- Cell, 2014, 158(5):989-999
- Cell, 2014, 157(4):882-896
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- Cell, 2013, 152(4):791-805
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- Cell, 2012, 149(2):307-21
- Cell, 2012, 151(7):1457-73
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- Cell, 2012, 150(5):987-1001
- Cell, 2012, 151(2):320-32
- Cell, 2012, 149(3):656-70
- Cell, 2012, 148(1-2):201-12
- Cell, 2011, 145(4):529-42
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- Cell, 2011, 147(4):853-67
- Cell, 2010, 142(3):444-55
- Cell, 2010, 142(4):590-600
Fourteen Nobel Prize winners have published 45 articles with Selleck products.
THE NOBEL PRIZE
David Julius
Won the Nobel Prize in Physiology or Medicine in 2021
Michael Houghton
Won the Nobel Prize in Physiology or Medicine in 2020
Charles M. Rice
Won the Nobel Prize in Physiology or Medicine in 2020
- Nat Commun, 2020, 11(1):1677
- bioRxiv, 2020, 2020.10.09.334128
- bioRxiv, 2020, 2020.01.20.910927
- Viruses, 2019, 11(11)E1039
- Cell Rep, 2018, 25(4):833-840.e3
- Cell, 2018, 172(3):423-438.e25
- Gastroenterology, 2017, 153(2):566-578.e5
- Gastroenterology, 2016, 150(1):82-85.e4
- Antimicrob, 2016, 60(6):3786-93
- Nature, 2015, 524(7566):471-5
- Antimicrob, 2015, 59(6):3482-92
- J Virol, 2014, 88(20):12098-111
- Antimicrob, 2014, 58(9):5386-94
- J Virol, 2013, 87(13):7593-607
- Nature, 2013, 501(7466):237-41
- Nature, 2013, 99(1):6-11
- Antimicrob, 2012, 56(10):5365-73
William G. Kaelin Jr
Won the Nobel Prize in Physiology or Medicine in 2019
Peter J. Ratcliffe
Won the Nobel Prize in Physiology or Medicine in 2019
Gregg L. Semenza
Won the Nobel Prize in Physiology or Medicine in 2019
James P. Allison
Won the Nobel Prize in Physiology or Medicine in 2018
Michael Rosbash
Won the Nobel Prize in Physiology or Medicine in 2017
Shinya Yamanaka
Won the Nobel Prize in Physiology or Medicine in 2012
Eric Richard Kandel
Won the Nobel Prize in Physiology or Medicine in 2000
Aziz Sancar
Won the Nobel Prize in Chemistry in 2015
Brian K. Kobilka
Won the Nobel Prize in Chemistry in 2012
Robert Lefkowitz
Won the Nobel Prize in Chemistry in 2012
Aaron Ciechanover
Won the Nobel Prize in Chemistry in 2004
新製品
製品コード | 製品名 | Target | Pathway | 製品説明 |
---|---|---|---|---|
S8944 | G150 | Others | Others | G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM. |
S8913 | TH5487 | Others | Others | TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM. |
S8938 | KGA-2727 | SGLT | GPCR & G Protein | KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models. |
S8939 | Mizagliflozin | SGLT | GPCR & G Protein | Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation. |
S7013 | Guadecitabine (SGI-110) | Others | Others | Guadecitabine (SGI-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine. |
S8812 | CM272 | DNA Methyltransferase | Epigenetics | CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death. |
S9729 | Visomitin (SKQ1) | Others | Others | INT-777 (S-EMCA) is a novel potent and selective TGR5 agonist with EC50 values of 0.18 μM, 3.9 μM and 1.45 μM for WT TGR5, TGR5(N76A) and TGR5(Y89F) respectively. |
S8500 | BAY1125976 | Akt | PI3K/Akt/mTOR | BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP). |